The N4 Boyle to Sligo road reopened on Thursday night following an earlier fatal road traffic collision between a car and a truck.
The collision took place in the townland of Tawnagh, close to Taylors Art Gallery shortly after midday.
The sole male occupant of the car was pronounced dead at the scene.
Diversions were put in place with the road opening shortly after 10pm Thursday night.
It is understood the man in his twenties is from the Carrick on Shannon area and was a student at Sligo IT.
Any witnesses are asked to contact Ballymote Garda Station on 071 9189500, the Garda Confidential Line 1800 666 111 or any Garda Station